Throughout the development of medicine, the spotlight has been held by the search for new
drugs blocking different types of arrhythmia. In the past decade, much attention was given to the selection
of active antiarrhythmic substances from plant material. It has been shown that these compounds
have a good antiarrhythmic effect, and their chemical modifications substantially increase their major
effects while adding other beneficial pharmacological properties. In this regard, work on the chemical
modification of plant-source antiarrhythmics is highly relevant to the development of new and promising
Keywords: Antiarrhythmic drugs, cardiovascular, chemical modifications, ischemic heart disease, plant substances, thyreoidea.
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