New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases

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The renin-angiotensin system (RAS) is a hormonal system that is responsible for regulating plasma sodium ion concentration and arterial blood pressure in the body. The system involves several ...
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Quantification of Angiotensins: Is there a Consensus in the Literature?

Pp. 337-358 (22)

Zaira Palomino Jara, Andreia Cristina Febba Gomes, Fernanda Barrinha Fernandes, Dale M Seth, Minolfa C. Prieto, L. Gabriel Navar and Dulce Elena Casarini

Abstract

The renin angiotensin system (RAS) is an essential regulator of renal and cardiovascular function. The components of this system are present in the circulation, organs, tissues and various cell types; and their syntheses in the organs are independent of the circulation. Understanding how the circulatory and organ RAS interact in the maintenance of the body function is knowledge that is not only key, but absolutely essential in helping us to unravel the implications of the RAS in a disease process. In this regard, this chapter aims to verify whether or not there is a consensus in the literature for the reported quantities and concentrations of Angiotensin I (Ang I), Angiotensin II (Ang II) and Angiotensin 1-7 (Ang1-7) in normal physiological states in mice, rats and humans. Because of the various methods for quantification of angiotensins, there is not presently a clear consensus for the absolute quantities of these peptides in plasma and the different tissues.

Keywords:

Angiotensins, Angiotensin converting enzyme (ACE), Angiotensin converting enzyme 2 (ACE2), Angiotensin I, Angiotensin II, Angiotensin 1-7, Consensus, Enzyme-linked immunosorbent assay (ELISA), Extraction of angiotensins, High performance liquid chromatography (HPLC), Liquid chromatography (LC) mass spectrometry (MS), Plasma angiotensins, Protease inhibitors, Radioimmunoassay (RIA), Tissue angiotensins.

Affiliation:

Rua Botucatu, 740 - 2° andar, Department of Medicine/Nephrology Division, Vila Clementino - Sao Paulo/SP, Brazil, CEP 04023-900.