New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases

Indexed in: EBSCO.

The renin-angiotensin system (RAS) is a hormonal system that is responsible for regulating plasma sodium ion concentration and arterial blood pressure in the body. The system involves several ...
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Renin-Angiotensin System in Animal Models of Diabetes and Hypertension

Pp. 322-336 (15)

Roseli Peres Moreira, Nadia de Sousa da Cunha Bertoncello, Rodolfo Mattar Rosa, Isabela Bezerra Loyola, Juliana Dineia Perez Brandao and Juliana Almada Colucci

Abstract

Translational research has currently become the focus of many ongoing studies. The use of inbred animals represents an advantage to human studies to a certain point because of the elimination of several uncontrollable variables. However, we need to consider the limitation of such approach in the translational potential to humans. Within the field of hypertension and diabetes research, animal models are irreplaceable research tools providing insight into human diseases. These two diseases independently predispose to renal and cardiovascular complications but, more importantly, can aggravate each other. Although some of the best models for diabetes and hypertension are spontaneous, the use of transgenic models provides a better control of the pathological mechanisms to be studied and the combination of the available tools will most likely make a difference in understanding how the RAS is modulated in diabetes and hypertension. Although these animals add a few layers of complexity and are sometimes closer to the human pathological mechanism, there are still many challenges to overcome.

Keywords:

Animal models, Basic research, Diabetes, Hypertension, In vivo studies, Knock out, Mice, Rats, RAS, Renin-angiotensin system, SHR, Spontaneously hypertensive rats, Transgenic, Translational medicine, Type 1 diabetes, Type 2 diabetes.

Affiliation:

Departamento de Medicina, Disciplina de Nefrologia, Universidade Federal de Sao Paulo Rua Botucatu, 740 Vila Clementino, Sao Paulo - SP 04023-900.