New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases

Indexed in: EBSCO.

The renin-angiotensin system (RAS) is a hormonal system that is responsible for regulating plasma sodium ion concentration and arterial blood pressure in the body. The system involves several ...
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Angiotensin-(1-7) in the Heart

Pp. 92-109 (18)

Rodrigo Araújo Fraga-Silva, Anderson José Ferreira and Robson Augusto Souza dos Santos

Abstract

The renin-angiotensin system (RAS) is recognized as one of the most important modulators of the heart function, working intensely on maintaining cardiac homeostasis. Recent advances pointed out that this system is divided into two distinct counter-regulatory axes. The classical axis is well characterized and involves the formation and actions of the octapeptide Angiotensin (Ang) II, while the second axis has emerged in the last decades and has the heptapeptide Ang-(1-7) as the main effector. Ang-(1-7) modulates several aspects of the heart hemostasis, such as cardiac rhythm, contractility, hypertrophy, fibrosis and coronary flow. In this chapter, we will summarize the current literature addressing the role of Ang-(1-7) and its receptor Mas in the heart function and structure, highlighting its beneficial activities under pathological conditions.

Keywords:

Angiotensin-converting enzyme, Angiotensin-converting enzyme 2, Angiotensin-(1-7), Angiotensin II, Cardiac homeostasis, Cardiac remodeling, Cardiac rhythm, Heart, Receptor Mas, Renin-angiotensin system.

Affiliation:

Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, Av. Antonio Carlos, 6627 – UFMG, 31270-901 – Belo Horizonte, MG, Brasil.