Background: In the last two decades, multi-particulate dosage forms have caught the attention
of formulation scientists due to their tremendous potential as a drug delivery system with a broad range of
Methods: Recent patented technologies are focused on designing multi-particulate systems that can enhance
therapeutic efficacy and oral bioavailability with minimum systemic toxicity. The technologies
offer opportunities to the manufacturers for increasing their market share, especially for competitive generics,
and also establishing intellectual property positions.
Results: The present paper provides an overview of advanced technologies and patents, based on different
principles, for designing multi-particulate dosage forms. The review covers basic characteristics of the
current technologies, the mechanisms by which they overcome the limitations of conventional oral dosage
forms, and their applications.
Conclusion: Comprehensive knowledge of these technologies will expedite further development and
platform technologies for multi-particulate controlled drug delivery systems.