Background: A series of new symmetric disulfonamide and dicarbamate derivatives of 4,4ˈ-
oxydianiline were designed and synthesized in a simple method. These compounds were characterized
by IR, 1H, 13C-NMR, mass spectral data and elemental analysis.
Method: The compounds were screened for their in vitro antibacterial and antifungal activities against
various pathogenic organisms. Among the title compounds 10f, 10a and 10h showed promising antibacterial
activity and 10g, 10d and 10a showed good antifungal activity.
Conclusion: The results also emphasized that the disulfonamide derivatives were better antibacterial
agents than the corresponding dicarbamate derivatives.
Keywords: 4, 4'-oxydianiline, disulfonamides, false metabolite, dicarbamates, sulphorhodamine-B (SRB) assay method, antibacterial
activity, antifungal activity.
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