Association Between Waist Circumference and Magnesium and Uric Acid in Indigenous Argentinean Children Living at High Altitude

Author(s): Valeria Hirschler, M. Esteban, Claudio D. Gonzalez, Claudia Molinari, Luis Castano.

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)

Volume 14 , Issue 2 , 2016

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Graphical Abstract:


Background: Non-traditional risk factors including low levels of magnesium and high levels of uric acid have been associated with central obesity and cardiovascular disease.

Objective: To determine the association between waist circumference (WC) and non-traditional risk factors such as magnesium, phosphorus, and uric acid in indigenous children living at high altitudes.

Methods: A total of 354 (166 M) indigenous school children, aged 9.6 + 2.3 years, were enrolled in a cross-sectional study in November 2011. Central obesity was defined as WC ≥ 90th percentile according to age and sex. Low magnesium and phosphorus levels were defined as serum magnesium <1.8 mg/dL and phosphorus <2.4 mg/dL. Hyperuricemia was defined as serum uric acid > 7 mg/dL.

Results: The prevalence of central obesity was 6.8% (24/354). None of the children had hyperuricemia or low phosphorus levels. Hypoagnesemia was identified in 21.7% (57/263). There was a significant association between WC (z-score) and magnesium (r-015), uric acid (r0.28), phosphorus (r-0.30), HOMAIR (r0.49), triglycerides (r0.24), and HDL-C (r0.24). However, calcium, sodium, and potassium were not significantly associated with WC. As z-WC quartiles increased magnesium and phosphorus levels significantly decreased, whereas uric acid levels increased. Multiple linear regression analysis showed that z-WC was associated significantly and directly with uric acid (B0.31), triglycerides (B0.004), and HOMA-IR (B0.35); and inversely with magnesium (B-0.83) and phosphorus (B-0.25), adjusted for confounding variables (R2 0.34).

Conclusion: Our results indicate that central obesity was associated significantly and inversely with magnesium and phosphorus and directly with uric acid in indigenous school children. Supplementation with magnesium and/or phosphorus could prevent future cardiovascular disease. Prospective and randomized studies should be performed to confirm these findings.

Keywords: High altitude, indigenous children, magnesium, phosphorus, uric acid, waist circumference.

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Article Details

Year: 2016
Page: [134 - 140]
Pages: 7
DOI: 10.2174/1871529X16666161027165250
Price: $58

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PDF: 17