The incidence and mortality due to breast cancer is increasing worldwide. There is a constant quest to
know the underlying molecular biology of breast cancer in order to arrive at diagnosis and plan better treatment
options. MicroRNAs (miRNAs) are small non-coding and single stranded RNAs which influence the gene expression
and physiological condition in any tumor. The miRNAs may act on different pathways in various cancers.
Recently, there are research reports on various miRNAs being linked to breast cancers. The important miRNAs
associated with breast cancers include miR-21, miR-155, miR-27a, miR-205, miR-145 and miR-320a. In the
present review we discuss the role of miRNAs in breast cancer, its importance as diagnostic markers, prognosis
and metastasis markers. We also highlight the role of miRNAs with regard to resistance to few anticancerous
drugs such as Tamoxifen and Trastuzumab. The role of miRNA in resistance to treatment is one of the core issues
discussed in the present review. Much information on the miRNA roles is available particularly in the neoadjuvant
chemotherapy setting, because this protocol allows the rapid association of miRNA expression with the
treatment response. This review opens the door for designing better therapeutic options in drug resistance cases in
Keywords: miRNAs, expression, breast cancer, marker, treatment, resistance.
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