A lot of effort has been devoted to achieving active targeting for cancer therapy in order to reach the
right cells. Hence, increasingly it is being realized that active-targeted nanocarriers notably reduce off-target
effects, mainly because of targeted localization in tumors and active cellular uptake. In this context, by taking
advantage of the overexpression of transferrin receptors on the surface of tumor cells, transferrin-conjugated
nanodevices have been designed, in hope that the biomarker grafting would help to maximize the therapeutic
benefit and to minimize the side effects. Notably, active targeting nanoparticles have shown improved therapeutic
performances in different tumor models as compared to their passive targeting counterparts. In this review, current
development of nano-based devices conjugated with transferrin for active tumor-targeting drug delivery are
highlighted and discussed. The main objective of this review is to provide a summary of the vast types of nanomaterials
that have been used to deliver different chemotherapeutics into tumor cells, and to ultimately evaluate
the progression on the strategies for cancer therapy in view of the future research.
Keywords: Active-targeted drug delivery, nanocarriers, transferrin, tumor cells, cancer therapy.
Rights & PermissionsPrintExport