Background: Improvement of oral bioavailability through enhancement of dissolution for poorly soluble
drugs has been a very promising approach. Recently, mesoporous silica based molecular sieves have demonstrated
excellent properties to enhance the dissolution velocity of poorly water-soluble drugs.
Description: Current research in this area is focused on investigating the factors influencing the drug release from
these carriers, the kinetics of drug release and manufacturing approaches to scale-up production for commercial
Conclusion: This comprehensive review provides an overview of different methods adopted for synthesis of
mesoporous materials, influence of processing factors on properties of these materials and drug loading methods.
The drug release kinetics from mesoporous silica systems, the manufacturability and stability of these formulations
are reviewed. Finally, the safety and biocompatibility issues related to these silica based materials are discussed.