Pathogenesis-related (PR) proteins are components of innate immunity system in
plants. They play an important role in plant defense against pathogens. Lipid transfer proteins
(LTPs) and Bet v 1 homologs comprise of two separate families of PR-proteins. Both LTPs
(PR-14) and Bet v 1 homologs (PR-10) are multifunctional small proteins involving in plant
response to abiotic and biotic stress conditions. The representatives of these PR-protein families
do not show any sequence similarity but have other common biochemical features such as
low molecular masses, the presence of hydrophobic cavities, ligand binding properties, and
antimicrobial activities. Besides, many members of PR-10 and PR-14 families are ubiquitous
plant panallergens which are able to cause sensitization of human immune system and crossreactive
allergic reactions to plant food and pollen. This review is aimed at comparative
analysis of structure-functional and allergenic properties of the PR-10 and PR-14 families, as
well as prospects for their medicinal application.
Keywords: Innate immunity system, pathogenesis-related proteins, plant defense, Bet v 1 homologs, lipid transfer
proteins, ligand binding, allergens, cross reactivity.
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