Plant Pathogenesis-Related Proteins PR-10 and PR-14 as Components of Innate Immunity System and Ubiquitous Allergens

Author(s): Ekaterina I. Finkina, Daria N. Melnikova, Ivan V. Bogdanov, Tatiana V. Ovchinnikova*.

Journal Name: Current Medicinal Chemistry

Volume 24 , Issue 17 , 2017

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Pathogenesis-related (PR) proteins are components of innate immunity system in plants. They play an important role in plant defense against pathogens. Lipid transfer proteins (LTPs) and Bet v 1 homologs comprise of two separate families of PR-proteins. Both LTPs (PR-14) and Bet v 1 homologs (PR-10) are multifunctional small proteins involving in plant response to abiotic and biotic stress conditions. The representatives of these PR-protein families do not show any sequence similarity but have other common biochemical features such as low molecular masses, the presence of hydrophobic cavities, ligand binding properties, and antimicrobial activities. Besides, many members of PR-10 and PR-14 families are ubiquitous plant panallergens which are able to cause sensitization of human immune system and crossreactive allergic reactions to plant food and pollen. This review is aimed at comparative analysis of structure-functional and allergenic properties of the PR-10 and PR-14 families, as well as prospects for their medicinal application.

Keywords: Innate immunity system, pathogenesis-related proteins, plant defense, Bet v 1 homologs, lipid transfer proteins, ligand binding, allergens, cross reactivity.

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Article Details

Year: 2017
Page: [1772 - 1787]
Pages: 16
DOI: 10.2174/0929867323666161026154111
Price: $58

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