Background: Use of intra-articular antibiotics for the treatment of arthroplasty
infections has gained some interest over the last few years.
Objective: Some data exists on its use with bacterial arthroplasty infections.
Method: We used intra-articular amphotericin B in an attempt to cure these joint infections
and perform a one stage revision.
Results: Two patients were treated with intra-articular amphotericin B for 6 weeks
followed by suppressive fluconazole for 4 months. Intra-articular joint fluid was cultured
during this process for re-growth of fungus.
Conclusion: Both patients were treated successfully with the method with follow up
showing no evidence of recurrence. IA administration of amphotericin B may be an
alternative treatment in these patients.