Melissa of cinalis and Vitamin E as the Potential Therapeutic Candidates for Reproductive Toxicity Caused by Anti-cancer Drug, Cisplatin, in Male Rats

Author(s): Maryam Iman, Mostafa Araghi, Toktam Heidari, Vahid Mohammadi.

Journal Name: Recent Patents on Anti-Cancer Drug Discovery

Volume 12 , Issue 1 , 2017

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Abstract:

Background: High doses of Cisplatin (CP) can disrupt the normal functioning of various tissues such as ovaries and testis. In almost all the patients, spermiotoxicity of CP causes temporary or permanent azoospermia.

Objective: In this study, the defensive effect of Melissa ofcinalis and vitamin E against testicular injuries caused by CP in male rats was evaluated.

Method: Thirty six male rats were distributed into 6 groups. Group 1 was used as the negative control. In group 2, a single dose of CP (10 mg/kg) was administered on the first day. In groups 3 and 4, a single dose of CP (10 mg/kg) was administered on the first day and then treated with Melissa ofcinalis at 1000 mg/kg/day and vitamin E at 100 mg/kg/day for 7 consecutive days, respectively. Groups 5 and 6 were treated with Melissa ofcinalis and vitamin E for 7 consecutive days, respectively. After euthanasia, serum levels of testosterone, Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) were evaluated. Testes were removed and weighed. Spermatic analysis was done on the tail of the epididymis. Tissue lipid peroxidation and activity of antioxidant enzymes in testes were evaluated as well.

Results: The results showed that Melissa ofcinalis and vitamin E increased serum levels of testosterone, LH and FSH, weight of testes and sperm motility, count and vitality and decreased sperm cell abnormalities in rats given CP.

Conclusion: Our results are useful in designing a medication of Melissa ofcinalis that can protect the testes against CP-induced testicular damage and infertility in cancerous male patients.

Keywords: Antioxidant, cisplatin, Melissa ofcinalis, reproductive toxicity, vitamin E.

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Article Details

VOLUME: 12
ISSUE: 1
Year: 2017
Page: [73 - 80]
Pages: 8
DOI: 10.2174/1574892811666161026111721
Price: $58

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