Introduction for Design of Nanoparticle Based Drug Delivery Systems

Author(s): Jun Yan Chan Edgar , Hui Wang* .

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 14 , 2017

Abstract:

Conventional drug delivery systems contain numerous limitations such as limited targeting, low therapeutic indices, poor water solubility, and the induction of drug resistances. In order to overcome the drawbacks of conventional pathway of drug delivery, nanoparticle delivery systems are therefore designed and used as the drug carriers. Nanoparticle based drug delivery systems have been rapidly growing and are being applied to various sections of biomedicine. Drug nanocarriers based on dendrimers, liposomes, self-assembling peptides, watersoluble polymers, and block copolymer micelles are the most extensively studied types of drug delivery systems and some of them are being used in clinical therapy. In particular for cancer therapy, antineoplastic drugs are taking advantage of nanoparticulate drug carriers to improve the cure efficacy. Nanoparticle based drug carriers are capable of improving the therapeutic effectiveness of the drugs by using active targeting for the site-specific delivery, passive targeting mechanisms such as enhanced permeability and retention (EPR), de novo synthesis and uptake of low density liposome in cancer cells or by being water-soluble to improve the suboptimal pharmacokinetics in limited water-soluble delivery methods.

Keywords: Drug delivery, encapsulation, tumor targeted delivery, dendrimers, liposome, self-assembling peptides, water-soluble polymers, block copolymer micelles.

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Article Details

VOLUME: 23
ISSUE: 14
Year: 2017
Page: [2108 - 2112]
Pages: 5
DOI: 10.2174/1381612822666161025154003
Price: $58

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