Introduction: With the development of the direct acting antivirals aganist hepatitis C virus
(HCV), the treatment of HCV has showed significiant progress. However, hepatitis B virus (HBV) therapy
is still a topic of discussion.
Objectives: Because of that approved agents for HBV have some disadvantages including indefinite
therapy, drug resistance, adverse effects and persistence of covalently closed circular deoxyribonucleic
acid (cccDNA), there is a need for new treatment targets and approaches for HBV. And, there are several
trials about this subject. New treatment targets for HBV consist revers transcription, immunoregulation,
cccDNA formation and regulation, maturation and secretion of infectious virions and subviral particules,
viral receptor, entry and cytosolic transport, nucleocapsid assembly. Therapeutic vaccination and
traditional Chinese medicine are the other options for novel agents for HBV treatment. We summarised
new treatment targets and approaches for HBV.
Conclusion: It is a certain fact that large-scale studies about all these molecules and approaches are required,
in order to highlight the efficiency, drug interaction, safety and appropriate dose.