Assessment of Mortality Risk in Elderly Persons with Obstructive Sleep Apnea Diagnosed with Pneumonia

Title:Assessment of Mortality Risk in Elderly Persons with Obstructive Sleep Apnea Diagnosed with Pneumonia

Volume: 12 Issue: 4

Author(s): Charlisa D. Gibson, Eric Yudelevich, Raymond A. Jean, Pius Ochieng and Raymonde E. Jean

Affiliation:

Keywords: Elderly, pneumonia, sleep apnea.

Abstract: Objective: Aging is associated with increased risk of obstructive sleep apnea (OSA) and treatment of OSA in elderly is of great interest but controversial. Pneumonia requiring invasive mechanical ventilation (IMV) is a leading cause of death in the elderly. The purpose of the study was to assess pneumonia-related mortality in elderly persons with OSA.

Methods: The Nationwide Inpatient Sample (NIS) was investigated for discharges with a primary or secondary diagnosis of pneumonia between 2009 and 2011. Persons with OSA, aged 65 years and older, were compared to a cohort of patients without OSA. Primary outcomes were in-hospital mortality and non-routine discharge (discharge to nursing home or skilled facility). Logistic regression models were used to assess the risk of OSA on in-hospital mortality and discharge status.

Results: In 1,768,185 hospital discharges, approximately 5% had OSA, and its prevalence was inversely proportional to age (65-74: 8.3%, 75-84: 4.8%, 85+: 1.8%). Pneumonia requiring IMV was more common in the OSA cohort (OSA: 4.3% vs. Non-OSA: 3.3% <0.0001). In-hospital mortality (OSA: 3.3% vs. Non-OSA 5.1% <0.0001) and non-routine discharges (OSA: 46.9% vs. Non-OSA: 55.4% <0.0001) were significantly lower in the OSA group.

Conclusion: OSA was associated with reduced inpatient mortality risk in pneumonia related respiratory failure in elderly subjects. Sleep apnea may confer a survival benefit in older individuals; but further research is warranted.

Cite this article as:

Gibson D. Charlisa, Yudelevich Eric, Jean A. Raymond, Ochieng Pius and Jean E. Raymonde, Assessment of Mortality Risk in Elderly Persons with Obstructive Sleep Apnea Diagnosed with Pneumonia, Current Respiratory Medicine Reviews 2016; 12 (4) . https://dx.doi.org/10.2174/1573398X12666161025111557

DOI https://dx.doi.org/10.2174/1573398X12666161025111557	Print ISSN 1573-398X
Publisher Name Bentham Science Publisher	Online ISSN 1875-6387