Objective: Simple and sensitive UV method was developed and validated for the determination
of meclizine hydrochloride in formulation, based on binary complex formation with eosin Y.
Method: The absorbance of the formed complex was measured at 540 nm. Beer's law was obeyed in the
range of 5-25 µgmL-1 with r2 value 0.9960.
Results: The method showed good value of accuracy and precision (%RSD=1.096), and the limits of
detection and quantification of the method were 0.76 and 2.29 µgmL-1, respectively. The analytical performance
of the method was fully validated, and the results were satisfactory. The method can be applied
successfully for the assay of meclizine hydrochloride in commercial tablets containing the drug
alone or in combination.
Conclusion: This method provides a valid alternative of reported methods for the determination of meclizine
in formulations as it's a simple, less time and cost consuming and can be applied for pharmaceutical
analysis in pharmaceutical industries.