Abstract
Background: Oxidative stress (OS) arises when the balance between the production of oxidants and their removal is disturbed; OS is associated with a wide variety of health disorders. Finding strategies that efficiently reduce OS is an active area of research.
Objective: This review summarizes the chemical insights concerning the antioxidant capacity (AOC) of melatonin and related compounds.
Method: We consider not only naturally-occurring but also synthetic derivatives. Different chemical routes that may be involved in their AOC are analyzed and some trends in activity are provided.
Conclusion: Based on the data gathered so far it can be stated that melatonin and related compounds constitute a chemical family with remarkable protective effects against OS. Their action includes both primary and secondary AOC, and -collectively- they can be considered as multifunctional protectors against OS. Current challenges and future perspectives in this area of research are discussed.
Keywords: Antioxidant activity, free radical scavenging, metal chelation, reaction mechanisms, kinetics, rate constants, trends in activity.
Current Organic Chemistry
Title:Melatonin and Related Compounds: Chemical Insights into their Protective Effects Against Oxidative Stress
Volume: 21 Issue: 20
Author(s): Annia Galano, Dun-Xian Tan and Russel J. Reiter*
Affiliation:
- Department of Cellular and Structural Biology, UT Health Science Center, San Antonio, Texas, TX,United States
Keywords: Antioxidant activity, free radical scavenging, metal chelation, reaction mechanisms, kinetics, rate constants, trends in activity.
Abstract: Background: Oxidative stress (OS) arises when the balance between the production of oxidants and their removal is disturbed; OS is associated with a wide variety of health disorders. Finding strategies that efficiently reduce OS is an active area of research.
Objective: This review summarizes the chemical insights concerning the antioxidant capacity (AOC) of melatonin and related compounds.
Method: We consider not only naturally-occurring but also synthetic derivatives. Different chemical routes that may be involved in their AOC are analyzed and some trends in activity are provided.
Conclusion: Based on the data gathered so far it can be stated that melatonin and related compounds constitute a chemical family with remarkable protective effects against OS. Their action includes both primary and secondary AOC, and -collectively- they can be considered as multifunctional protectors against OS. Current challenges and future perspectives in this area of research are discussed.
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Cite this article as:
Galano Annia, Tan Dun-Xian and Reiter J. Russel*, Melatonin and Related Compounds: Chemical Insights into their Protective Effects Against Oxidative Stress, Current Organic Chemistry 2017; 21 (20) . https://dx.doi.org/10.2174/1385272820666161024124058
DOI https://dx.doi.org/10.2174/1385272820666161024124058 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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