Background: Chronic kidney disease (CKD) is a worldwide public health problem and an
independent risk factor for cardiovascular disease (CVD).
Objective: We assessed cardiovascular risk in end-stage renal disease (ESRD) patients and evaluated the
relationship between serum uric acid (SUA) and lipoprotein subfractions.
Methods: The study group consisted of 66 patients on dialysis and a control group of 25 healthy volunteers.
Concentration of high-density lipoproteins (HDL) and low-density lipoproteins (LDL) subfractions
were analysed using a Lipoprint™. Lipid profiles and SUA were measured.
Results: Statistically significant differences between control and study group both with increased and
normal SUA level were observed for HDL subfractions (1-5 [p = 0.0014 – 0.0001] and 7 – 10 [p=0.016],
large and small HDL subfractions [p<0.0001]), LDL-2 subfraction [p = 0.016] and IDL-B [p = 0.015]. A
significant decrease by 66% in CVD prevalence was found in dialysis patients with increased level of
SUA (> 428 mol/l) (p = 0.034). Association between SUA and CVD prevalence was independent of
large, intermediate and small HDL subfractions as well as of very low-density lipoprotein (VLDL), intermediate-
density lipoproteins-C, -B, -A (IDL-C, IDL-B and IDL-A).
Conclusion: Our study demonstrated that higher SUA level might be associated with lower prevalence of
CVD among haemodialysis patients. An elevated SUA concentration in haemodialysis population may be
a marker of better nutritional status and also represent the antioxidant properties SUA.