Synthesis and Antiproliferative Activities of Novel O-Benzyl Salicylamide Derivatives

Author(s): Jan Dusek, Ales Imramovsky, Karel Pauk, Radek Jorda, Eva Reznickova, Vladimir Krystof.

Journal Name: Letters in Drug Design & Discovery

Volume 14 , Issue 6 , 2017

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Abstract:

Background: On the basis that various substituted salicylamides have shown interesting biological properties, we designed and synthesized new salicylamide derivatives with dipeptide moieties.

Methods: The synthesis was based on the gradual building of target molecules and provided optically pure compounds.

Conclusion: The obtained compounds were tested for their antiproliferative effect against three leukaemia cell lines in vitro and displayed GI50 values in the mid-micromolar range.

Keywords: Salicylamides, antiproliferative activity, cytotoxic activity, pharmacological activity, amines.

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2017
Page: [662 - 671]
Pages: 10
DOI: 10.2174/1570180813666161020113827
Price: $58

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