Background: Pharmaceutical cocrystal is an emerging approach to tailor physicochemical and
mechanical properties of drug substances. Cocrystals are composed of API and pharmaceutically acceptable
coformer. It is used to address the solubility, dissolution, mechanical properties and stability of drugs.
Methods: This review discusses introduction to cocrystal, preparation, and characterization, what USFDA
says on cocrystal and role of Hansen solubility parameter to predict cocrystal. The effect of cocrystal
on drug properties, dependence of cocrystal solubility on pH, concept of drug-drug cocrystal,
and aerosil 200 as novel cocrystal former and impact of cocrystal on drug pharmacokinetic has also
been presented in this review along with highly selected examples of cocrystals. Finally, how cocrystal
offers an opportunity for patents is also delineated.
Results: Pharmaceutical cocrystals have ability to tailor physichochemical and mechanical properties
of drug substances. It also provides opportunity for patentable invention. Therapeutic efficacy of
drugs may be improved via drug-drug cocrystal.
Conclusion: The pharmaceutical cocrystals are not fully explored and have potential for future development.
Successful drug delivery can be achieved through cocrystallization. Pharmaceutical industry
will be beneficial through successful cocrystallization of drug substances.