Abstract
Background: Cascade reactions are well-known as powerful process to design complex molecular structures from simple and cheap starting compounds by using two or more reactions in a single consecutive transformation. These reactions, forming a number of bonds by one operation, are useful for the creation of polycyclic and spirocyclic compounds. Thus, cascade reactions play important role in modern organic chemistry. The importance of cascade reactions are based not only on contemporary demands for more efficient and less labour-consuming methodologies for the synthesis of pharmaceuticals and other fine chemicals, but also from growing necessity to coincide the modern environmental demands. The development of electrosynthesis during last few decades have created a lot of important synthetic methodologies in the field of modern organic synthesis. Electroorganic synthesis is known as an environmentally benign methodology for many redox processes, since utilization of reagents with expressed toxicity are substituted by electric current, and the quantity of waste thus, tends to be considerably diminished. The electrochemical step is often only the first reaction in complex multi-step process, but it plays important role in producing starting reactive intermediates. Thus, organic electrochemistry offers remarkable alternatives to usual organic synthetic methods and creates a modern tool for carrying out organic synthesis.
Objective: The review deals with the last trends of the application of electrochemical methods to start the assembling of heterocyclic compounds by cascade reactions.Keywords: Electrochemical synthesis, heterocycles, cascade reactions, cathodic processes, anodic processes, paired electrosynthesis, mediators.
Graphical Abstract
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
55
6