One of the biggest challenges in the modern medicine and the food industry is to provide chemical
agents that, incorporated in the foods, could have some pharmacological properties, but mainly that can protect
and preserve our health from oxidative stress, and could be used in clinical treatments against some chronic diseases
with minor side effects. In this sense, aporphine alkaloids have been the group of nitrogen compounds more
studied in nature, incorporated in many foods and with a wide therapeutic application. Examples such as ()-
boldine (12), ()-liridinine (15), (+)-lirinidine (16) and glaucine (24) have been studied for their interesting antioxidant
activity and, in case of 24, synthetic modifications have managed to generate derivatives that exhibit
more efficient antioxidant activity. Therefore, clinical treatment against oxidative stress-related diseases, such as
Parkinson´s disease, anticancer, antinociceptive, therapeutic applications among other mentioned in this review,
gives the possibility of using these aporphine alkaloids of low cytotoxicity as an excellent alternative in the development
of new therapeutic patterns using the duplicity; biologically active ingredient-antioxidant.
Keywords: Aporphines, oxoaporphines, antioxidant, free radical scavengers, oxidative stress, Parkinson's disease, anticancer, antinociceptive.
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