Background: In the present study, a series of 5,7-disubstituted-2-phenyl-5H-[1,3,4]
thiadiazolo[3,2-a]pyrimidine derivatives have been reported. The title compounds were synthesized by
the reaction of substituted chalcones with 5-phenyl-1,3,4-thiadiazol-2-amine in n-butanol.
Methods: All reactions were performed at reflux temperature and the synthesized compounds were
characterized by IR, NMR and Mass spectroscopic techniques.
Results: The synthesized compounds were screened for their antimicrobial and antioxidant activities.
The compounds displayed significant antimicrobial and antioxidant activities. Additionally, the selected
compounds were screened for in silico molecular docking studies.
Conclusion: In the present work, we have reported an efficient method for the synthesis of some new
5,7-disubstituted-2-phenyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidine derivatives. Collectively, all the current
computational insights support the in vitro observations seen for antimicrobial and antioxidant
agents. Further, the pyrimidine derivatives might act as potential specific inhibitors of G6P synthase
thereby facilitating its biological activities. From the activity results, it has been concluded that among
the studied compounds, compounds 5b, 5d, 5e, 5g, 5i, 5m and 5n could serve as potential antimicrobial
and antioxidant agents.