Background: Sponges are rich source of bioactive natural products synthesized by the symbiotic bacteria
belonging to different phyla. Due to a competition for space and nutrients the marine bacteria associated with sponges
could produce more antibiotic substances. To explore the proactive potential of marine microbes extensive research has
been done. These bioactive metabolites have some unique properties that are pharmaceutically important.
Methods: For this review, we have performed a non-systematic search of the available literature though various online
search engines. This review provides an insight that how majority of active metabolites have been identified from
marine invertebrates of which sponges predominate.
Results: Sponges harbor abundant and diverse microorganisms, which are the sources of a range of marine bioactive
metabolites. From sponges and their associated microorganisms, approximately 5,300 different natural compounds are
known. Current research on sponge-microbe interaction and their active metabolites has become a focal point for many
researchers. Various active metabolites derived from sponges are now known to be produced by their symbiotic microflora.
Conclusion: In this review, we attempt to report the latest studies regarding capability of bacteria from sponges as
producers of bioactive metabolite. Moreover, these sponge associated bacteria are an important source of different
enzymes of industrial significance. In present review, we will address some novel approaches for discovering marine
metabolites from bacteria that have the greatest potential to be used in clinical treatments.