Role of Reactive Oxygen Species in Premature Ageing of the Female Reproductive Function

Author(s): Andrew Korenevsky, Yulia Milyutina, Ljudmila Kozina, Gleb Kerkeshko, Alexander Arutjunyan.

Journal Name: Current Aging Science

Volume 10 , Issue 1 , 2017

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Graphical Abstract:


Industrial xenobitics, as well as endogenous damaging factors, such as L-homocysteine, are a well-known source of reactive oxygen species that disrupt biological processes. Among many others, luteinizing hormone releasing hormone synthesis and secretion mediated by a variety of neurotransmitters, which are under control of the hypothalamus and pineal gland, may be put in peril by reactive oxygen species. Their formation can be one of the reasons for the reproductive function shutdown in ageing as the generic response to the damaging factors independent of their nature. We review recent findings demonstrating the role of reactive oxygen species in disrupting the circadian signal originated in the main pacemaker of the organism, the suprachiasmatic nuclei of the hypothalamus, on its way to the hypothalamic areas responsible for the luteinizing hormone preovulatory surge.

Keywords: Ageing, reproduction, biogenic amines, circadian rhythm, hypothalamus, reactive oxygen species, xenobiotics, melatonin.

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Article Details

Year: 2017
Page: [26 - 31]
Pages: 6
DOI: 10.2174/1874609809666161006111645
Price: $58

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