Background: Our recent findings have demonstrated that electromagnetic radiations (EMR)
(1.8 GHz radiofrequency) are able to in vitro induce morphometrical and morphological modifications of
human leukocytes from normal donors.
Methods: In view of the evidence that polyphenols exert many beneficial effects on plants, animals and
humans, leukocytes from human peripheral blood were pre-treated for 1 h with two polyphenol
preparations from red grape before EMR exposure (1.8 GHz).
Results: Our data will show that polyphenol pre-treatment reverts to normality the morphology of
irradiated leukocytes in comparison to irradiated cells only. Conversely, leukocyte morphometry seems to
be not affected by this treatment.
Conclusion: Here, we demonstrate that polyphenols are also able to normalize leukocyte morphology per
se altered before as well as after irradiation. Finally, a working hypothesis aimed at clarifying the
protective mechanisms exerted by polyphenols on irradiated leukocytes will be illustrated.