Morphometrical and Morphological Alterations of Human Leukocytes Exposed to 1.8 GHz Electromagnetic Radiations: In Vitro Protective Effects Induced by Polyphenols

Author(s): Pier Francesco Biagi , Sara Boffola , Riccardo Stefanelli , Luigi Schiavulli , Teresa Ligonzo , Giuseppe Casamassima , Maria Teresa Pappagallo , Kiichiro Kawaguchi , Hiroaki Takimoto , Yoshio Kumazawa , Sergio Fontana , Flavia Laforgia , Matteo Antonio Russo , Thea Magrone , Emilio Jirillo .

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets

Volume 16 , Issue 3 , 2016

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Graphical Abstract:


Background: Our recent findings have demonstrated that electromagnetic radiations (EMR) (1.8 GHz radiofrequency) are able to in vitro induce morphometrical and morphological modifications of human leukocytes from normal donors.

Methods: In view of the evidence that polyphenols exert many beneficial effects on plants, animals and humans, leukocytes from human peripheral blood were pre-treated for 1 h with two polyphenol preparations from red grape before EMR exposure (1.8 GHz).

Results: Our data will show that polyphenol pre-treatment reverts to normality the morphology of irradiated leukocytes in comparison to irradiated cells only. Conversely, leukocyte morphometry seems to be not affected by this treatment.

Conclusion: Here, we demonstrate that polyphenols are also able to normalize leukocyte morphology per se altered before as well as after irradiation. Finally, a working hypothesis aimed at clarifying the protective mechanisms exerted by polyphenols on irradiated leukocytes will be illustrated.

Keywords: Electromagnetic radiations, leukocytes, morphology, morphometry, polyphenols.

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Article Details

Year: 2016
Page: [189 - 196]
Pages: 8
DOI: 10.2174/1871530316666161003153024
Price: $58

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