Morphometrical and Morphological Alterations of Human Leukocytes Exposed to 1.8 GHz Electromagnetic Radiations: In Vitro Protective Effects Induced by Polyphenols

Author(s): Pier Francesco Biagi, Sara Boffola, Riccardo Stefanelli, Luigi Schiavulli, Teresa Ligonzo, Giuseppe Casamassima, Maria Teresa Pappagallo, Kiichiro Kawaguchi, Hiroaki Takimoto, Yoshio Kumazawa, Sergio Fontana, Flavia Laforgia, Matteo Antonio Russo, Thea Magrone, Emilio Jirillo.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets

Volume 16 , Issue 3 , 2016

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Graphical Abstract:


Background: Our recent findings have demonstrated that electromagnetic radiations (EMR) (1.8 GHz radiofrequency) are able to in vitro induce morphometrical and morphological modifications of human leukocytes from normal donors.

Methods: In view of the evidence that polyphenols exert many beneficial effects on plants, animals and humans, leukocytes from human peripheral blood were pre-treated for 1 h with two polyphenol preparations from red grape before EMR exposure (1.8 GHz).

Results: Our data will show that polyphenol pre-treatment reverts to normality the morphology of irradiated leukocytes in comparison to irradiated cells only. Conversely, leukocyte morphometry seems to be not affected by this treatment.

Conclusion: Here, we demonstrate that polyphenols are also able to normalize leukocyte morphology per se altered before as well as after irradiation. Finally, a working hypothesis aimed at clarifying the protective mechanisms exerted by polyphenols on irradiated leukocytes will be illustrated.

Keywords: Electromagnetic radiations, leukocytes, morphology, morphometry, polyphenols.

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Article Details

Year: 2016
Page: [189 - 196]
Pages: 8
DOI: 10.2174/1871530316666161003153024
Price: $58

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