Title:Drug Metabolism and Pharmacokinetics of Dammarane Triterpenoids
VOLUME: 17 ISSUE: 9
Author(s):Sainan Zhang and Yuqing Zhao
Affiliation:Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenhe District, Shenyang 110016, Liaoning, P. R. China.
Keywords:Dammarane triterpenoids, drug metabolism, radiolabel, absorption, distribution, metabolism, excretion, pharmacokinetics.
Abstract:Dammarane triterpenoids are widely distributed in plants and are implicated in various
bioactivities and pharmacological effects. This review focuses on advancements in dammarane
triterpenoid metabolism, particularly drug design and development, including radiolabeling,
absorption, distribution, metabolism, excretion, and pharmacokinetics, which can accurately
describe the behaviors of dammarane triterpenoids. This review contributes to the systematic and
consistent research and development of dammarane triterpenoids. Their structures and activities,
radiolabel application, absorption, distribution, and pharmacokinetic characteristics, possible
degradation pathways, metabolic enzyme induction or inhibitory effect, and structure-activity
relationships have been described. New intranasal and intra-tympanic administration routes and
microdialysis technology have also been introduced. These techniques not only improve the
limits of dammarane triterpenoids on absorption and distribution but also facilitate the design and study of these compounds
as potential drugs.
