Background: Diabetic retinopathy is one of the serious complications of diabetes and the
leading cause of decreased vision and blindness worldwide. Neurodegeneration has been recognized as
initiating factor in causing the retinal damage, which leads to micro-vascular damage in diabetic retinopathy.
Diabetes-induced oxidative stress is believed to be the key factor that damages neurons in the
diabetic retina. Various therapeutic approaches for effective attenuation of increased oxidative stress by
antioxidants have emerged. One such approach is to utilize dietary flavonoids, which have been found to
possess powerful antioxidant activity. Some of the naturally occurring flavones possess anti-diabetic effects
by enhancing insulin sensitivity and reducing plasma glucose levels in diabetic animal models.
Objective: Considering the importance of developing new antioxidant compounds and the relevance
of their applications in the treatment of diabetes and its complications, in this review article, we discuss
and highlight various neuroprotective mechanisms of flavonoids in the diabetic retina.
Results: Dietary supplementation of flavonoids to diabetics may reduce oxidative stress, which in turn
might ameliorate apoptosis and the levels of neurotrophic factors in the diabetic retina.
Conclusion: This approach will elucidate a novel strategy for preventing and treating diabetic retinoneuropathy
the leading cause of low vision and blindness.