Background: Studies have already shown that hyperglycemia and insulin resistance are
significantly associated with the impairment of cerebral glucose metabolism that may secondary lead to
cognitive disturbances. In this study, we aimed to evaluate the neurometabolic correlates of diabetes in a
patient with Intermittent explosive disorder (IED).
Methods: We have investigated the cerebral glucose metabolism via 2-[18F]-fluoro-2- deoxy-D-glucose
positron emission tomography (FDG-PET) in a diabetic patient with aggressive outbursts.
Results: We have found significantly reduced glucose uptake in left temporoparietal region, pontin area,
and left nucleus lentiformis.
Discussion: Our present results indicate decreased cerebral glucose metabolism in specific cerebral
cortical and subcortical areas. The main limitation of this report is that, this is a single case study and that
these findings need to be replicated in well- conducted randomized controlled studies by using additional