Calixarene: A Versatile Material for Drug Design and Applications

Author(s): Muhammad A. Hussain*, Muhammad U. Ashraf, Gulzar Muhammad, Muhammad N. Tahir, Syed N. A. Bukhari.

Journal Name: Current Pharmaceutical Design

Volume 23 , Issue 16 , 2017

Become EABM
Become Reviewer

Abstract:

The therapy of various diseases by the drugs entrapped in calixarene derivatives is gaining attraction of researchers nowadays. Calixarenes are macrocyclic nano-baskets which belong to cavitands class of host-guest chemistry. They are the marvelous hosts with distinct hydrophobic three dimensional cavities to entrap and encapsulate biologically active guest drugs. Calixarene and its derivatives develop inclusion complexes with various types of drugs and vitamins for their sustained/targeted release. Calixarene and its derivatives are used as carriers for anti-cancer, anti-convulsant, anti-hypertensive, anthelmentic, anti-inflammatory, antimicrobial and antipsychotic drugs. They are the important biocompatible receptors to improve solubility, chemical reactivity and decrease cytotoxicity of poorly soluble drugs in supramolecular chemistry. This review focuses on the calixarene and its derivatives as the state-of-the-art in host-guest interactions for important drugs. We have also critically evaluated calixarenes for the development of prodrugs.

Keywords: Calixarene, supramolecular, medicinal uses, drug release, prodrugs, drug design.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 23
ISSUE: 16
Year: 2017
Page: [2377 - 2388]
Pages: 12
DOI: 10.2174/1381612822666160928143328
Price: $58

Article Metrics

PDF: 34
HTML: 5