Cancer is the uncontrolled growth of cells in the body and is considered as one of
the major causes of death globally. There are several cytotoxic chemotherapeutic agents
used to treat cancer including methotrexate, 5-fluorouracil, cisplatin, tamoxifen, doxorubicin
and others. Although billions of dollars have been spent on cancer research to develop these
chemotherapies, it still remains a major illness for mankind partly due to the shortcomings
of these therapies. These shortcomings include low targeting specificity, severe side effects
(due to high doses) and poor pharmacokinetics. To avoid these drawbacks, anti-cancer drug
delivery systems have been developed recently using nanocarriers including liposomes, micelles,
polyelectrolyte capsules and others.
One of the recent class of nanoparticles investigated for chemotherapeutic use are metal organic
frameworks (MOFs) which are hybrid polymers that consist of metal ions or clusters
and organic ligands. MOFs are used in many applications including gas/vapor separation,
gas storage, catalysis, luminescent materials, and biomedical imaging. These structures have
additional features that promote their use as drug carriers in the biomedical field. First, they
are nontoxic, biodegradable and have the ability to carry high loadings of the anti-neoplastic
agent due to their porous nature. Also, they have well-defined crystalline structures that can
be characterized by different analytical techniques and their sizes are suitable to control
their in vivo drug release.
This paper reviews the methods used to synthesize MOFs and their recent use as antineoplastic
drug delivery carriers.