Role of Oxidative Stress in Hepatitis C Virus Induced Hepatocellular Carcinoma

Author(s): Na Fu, Hui Yao, Yuemin Nan*, Liang Qiao*.

Journal Name: Current Cancer Drug Targets

Volume 17 , Issue 6 , 2017

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Abstract:

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. Hepatitis C virus (HCV) infection is the predominant cause of chronic liver diseases and HCC, particularly in Western countries. Multiple molecular mechanisms are involved in the development and progression of HCV-related HCC, of which oxidative stress plays a pivotal role. HCV infection induces overproduction of reactive oxygen species (ROS) and impairs the function of endogenous antioxidants. Excessive amount of ROS directly damages DNA, lipids and proteins. Meanwhile, ROS indirectly activates a series of signaling cascades, and modulates the activity of many transcription factors, resulting in altered expression of genes that control cell survival, proliferation, angiogenesis, invasion and metastasis. In this review, we aim to summarize the possible molecular mechanisms underlying the link between the oxidative stress and hepatocarcinogenesis in HCV-infected individuals, in order to facilitate discovery of possible approaches or interventional targets for HCV-related HCC.

Keywords: Hepatitis C virus, oxidative stress, reactive oxygen species, hepatocellular carcinoma, chronic liver diseases.

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Article Details

VOLUME: 17
ISSUE: 6
Year: 2017
Page: [498 - 504]
Pages: 7
DOI: 10.2174/1568009616666160926124043
Price: $58

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