Background: Cardiovascular diseases are a group of disorders of the heart and blood vessels
that account for a major cause of premature death worldwide. Diosgenin saponin is a steroid for therapeutic
application in different clinical settings such as cardiovascular diseases, hyperglycemia and
dyslipidemia control, antimicrobial, anti-viral and anti-inflammatory agent. The aim of the study was to
conduct a systematic review of Diosgenin, its pharmaceutical applications and perspectives on the application
in the cardiovascular system diseases.
Methods: Periodic basis ScienceDirect, PubMed and Virtual Health Library were used as well as the
European Office of the technological bases Patent Office, World Intellectual Property Organization, the
Office US Patent and Trademark Office and the Brazilian database National Institute of Industrial Property.
The keywords used were Diosgenin, cardiovascular system, hypertension, atherosclerosis and
dyslipidemia and their correlations in English and Portuguese, with publications from January 2010 to
Results: After analysis of the technological and scientific bases, the results show that there is a limited
number of patents showing that the Diosgenin action on the cardiovascular system is centered in the areas
for chemical studies of steroid Diosgenin. In the scientific basis, the results show that there is an interesting
Diosgenin action on the cardiovascular system.
Conclusion: Therefore, studies with Diosgenin are promising on account of its significant pharmacological
potential from scientific and technological viewpoints, reaching for a technology transfer to generate
economic and industrial growth.