Pharmacological Effects of Biotin in Animals

Author(s): Leticia Riveron-Negrete, Cristina Fernandez-Mejia.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 17 , Issue 6 , 2017

Become EABM
Become Reviewer

Abstract:

In recent decades, it was found that vitamins affect biological functions in ways other than their long-known functions; niacin is the best example of a water-soluble vitamin known to possess multiple actions. Biotin, also known as vitamin B7 or vitamin H, is a water-soluble B-complex vitamin that serves as a covalently-bound coenzyme of carboxylases. It is now well documented that biotin has actions other than participating in classical enzyme catalysis reactions. Several lines of evidence have demonstrated that pharmacological concentrations of biotin affect glucose and lipid metabolism, hypertension, reproduction, development, and immunity. The effect of biotin on these functions is related to its actions at the transcriptional, translational, and post-translational levels. The bestsupported mechanism involved in the genetic effects of biotin is the soluble guanylate cyclase/protein kinase G (PKG) signaling cascade. Although there are commercially-available products containing pharmacological concentrations of biotin, the toxic effects of biotin have been poorly studied. This review summarizes the known actions and molecular mechanisms of pharmacological doses of biotin in animals and current information regarding biotin toxicity.

Keywords: Biotin toxicity, biotin, gene expression, guanylate cyclase, histone biotinylation, pharmacological effects.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 17
ISSUE: 6
Year: 2017
Page: [529 - 540]
Pages: 12
DOI: 10.2174/1389557516666160923132611
Price: $58

Article Metrics

PDF: 67
HTML: 4