Unraveling Antibody Display: Systems Biology and Personalized Medicine

Author(s): Luiz Ricardo Goulart , Paula Souza Santos , Ana Paula Carneiro , Barbara Brasil Santana , Antonio C. Vallinoto , Thaise Goncalves Araujo .

Journal Name: Current Pharmaceutical Design

Volume 22 , Issue 43 , 2016

Abstract:

Background: The identification of combinatorial antibodies against many different targets in oncology, autoimmune, inflammatory and infectious diseases has uncovered novel strategies to control and prevent diseases’ onset and progression, and represents the fastest growing market for the pharmaceutical industry. Phage Display has been successfully used in the identification of unknown targets, which combines shotgun approaches with high throughput selection schemes.

Methods: This specific review covers many aspects of combinatorial phage display technology starting from antibody selection strategies to its redesign for application purposes. Emphasis is specifically directed to how these biotherapeutics function on specific targets with an interactome view, especially within complex diseases.

Conclusion: Novel combinatorial antibodies will lead to improved interventions in cancer, autoimmune and infectious diseases; however, the very large genetic diversity associated with environmental variations highlight the importance of the personalized medicine using a system’s biology approach. Therefore, combined therapies are expected in the near future.

Keywords: Combinatorial antibodies, phage display, systems biology, cell signaling, cell therapy, personalized medicine.

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Article Details

VOLUME: 22
ISSUE: 43
Year: 2016
Page: [6560 - 6576]
Pages: 17
DOI: 10.2174/1381612822666160923112816
Price: $58

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