Background: Antibody phage display is highly dependent on the availability of
antibody libraries. There are several forms of libraries depending mainly on the origin of the
source materials. There are three major classes of libraries, mainly the naïve, immune and
Methods: Immune antibody libraries are designed to isolate specific and high affinity antibodies
against disease antigens. The pre-exposure of the host to an infection results in the
production of a skewed population of antibodies against the particular infection.
Results: This characteristic takes advantage of the in vivo editing machinery to generate bias
and specific immune repertoire. The skewed but diverse repertoire of immune libraries has
been adapted successfully in the generation of antibodies against a wide range of diseases.
Conclusion: We envisage immune antibody libraries to play a greater role in the discovery of antibodies for
diseases in the near future.