Mechanism and Anticancer Activity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv

Author(s): Qi Li, Yan Zhang, Jun-Ling Shi*, Yi-Lin Wang, Hao-Bin Zhao, Dong-yan Shao, Qing-Sheng Huang, Hui Yang, Ming-Liang Jin.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 17 , Issue 7 , 2017

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Abstract:

Backgroud: Pinoresinol (Pin) and pinoresinol monoglucoside (PMG) are plant-derived lignan molecules with multiple functions. We showed previously that an endophytic fungus from Eucommia ulmoides Oliv., Phomopsis sp. XP-8 is able to produce Pin and PMG.

Objective: This study was carried out to test the anti-tumor capability of the culture of XP-8 and identify the major effective compounds.

Method: The fungal culture was added in the culture of HepG2 and K562 cells, and the viabilities of these cells were detected and the possible mechanism was analyzed.

Result: The fungal culture showed significant capaiblity in decreasing the viability of tumor cells and induce apoptosis via up-regulation of the expression of apoptosis-related genes. It also significantly inhibited the adhesion and migration of HepG2 cells by blocking MMP-9 expression. Pin and PMG were isolated from the growth culture and shown to be the major effective components for inhibition. Conclusion: The study indicated the potential application of XP-8 in the production of anti-tumour products by the bioconversion of glucose.

Keywords: Apoptosis, caspase, inhibition effects, pinoresinol, pinoresinol monoglucosid.

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Article Details

VOLUME: 17
ISSUE: 7
Year: 2017
Page: [982 - 989]
Pages: 8
DOI: 10.2174/1871520616666160923094814
Price: $58

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