Sequential Therapy For Helicobacter pylori in Elderly Patients: Effectiveness, Safety and Predictors of Success

Author(s): Giuseppe Losurdo, Andrea Iannone, Floriana Giorgio, Michele Barone, Mariabeatrice Principi, Enzo Ierardi, Alfredo Di Leo.

Journal Name: Letters in Drug Design & Discovery

Volume 14 , Issue 4 , 2017

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Abstract:

Background: Sequential therapy is one of the most common regimens for H. pylori eradication. The progressive ageing may lead to several problems in the management of H. pylori.

Objective: We aimed to assess the effectiveness/safety of sequential therapy in elderly patients and evaluate possible predictive factors of failure.

Methods: We retrospecively enrolled 76 patients >65 years old (elderly group) and 69 controls diagnosed of H. pylori by upper endoscopy/histology and a non-invasive test. Patients received 10-day sequential therapy (esomeprazole 40 mg and amoxicillin 1 g for the first 5 days followed by clarithromycin 500 mg plus tinidazole 500 mg, all b.i.d). Comparison between groups was carried out by t-test or χ2 test where appropriate. Binomial logistic regression was used to determine factors influencing treatment failure.

Results: Eradication was achieved, at Intention-To-Treat analysis, in the 78.9% and 75.4% in the elderly and control group, respectively, and, at Per-Protocol analysis, in the elderly patients in the 81.1% and in controls in the 76.5%, not statistically different. Both groups experienced a similar rate of side effects (27% vs 26.5% p = 1). At univariate analysis, treatment failure in the elderly group positively correlated with female sex (OR=22.5), side effects (OR=5.3), intestinal metaplasia (OR=6.7) and gastric atrophy (OR=6.8), while negatively with antritis (OR=0.15). However, at multivariate analysis, none of the cited variables was found statistically significant.

Conclusion: Sequential therapy is safe in old patients and has satisfactory effectiveness, but an “a priori” model predicting the outcome based only on clinical data is not reliable.

Keywords: Helicobacter pylori, eradication, elderly, sequential therapy, metaplasia.

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Article Details

VOLUME: 14
ISSUE: 4
Year: 2017
Page: [500 - 505]
Pages: 6
DOI: 10.2174/1570180813666160922113541
Price: $58

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