Bacteriophage for Mitigation of Multiple Drug Resistant Biofilm Forming Pathogens

Author(s): Shilpa Deshpande Kaistha, Pramila Devi Umrao.

Journal Name: Recent Patents on Biotechnology

Volume 10 , Issue 2 , 2016

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Abstract:

Background: Microbial communities encased in exopolymeric substances (EPS) attached to suitable substrate as biofilms show heightened resistance to multiple drugs including antibiotics. One promising control strategy in dealing with the ever mounting problem of antibiotic resistance amongst biofilm forming bacterial pathogens is the use of biological agents.

Objective: This review focuses on the development of bacteriophages as means of disrupting biofilm forming pathogens and hence mitigation of multiple drug resistant organisms.

Results: Bacteriophages are obligatory viral intracellular parasites that can cause lytic infection of their bacterial hosts. Bacteriophage (Phage) therapy is advantageous in being highly host specific, safe and non-toxic to humans and hence environmental friendly. Bacteriophage induced lysis of cells within the biofilm is aided by the production of penetrating enzymes such as endolysins and EPS depolymerases as well quorum sensing inhibitors such as lactonases.

Conclusion: Phages are a promising alternative therapy for the control of multiple drug resistant (MDR) pathogens. Several phage (indigenous and engineered)/ phage products are currently being patented and developed as commercial biological control agents.

Keywords: Bacteriophage, Phage therapy, phage patents, multiple drug resistant, biofilm, intracellular parasites.

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2016
Page: [184 - 194]
Pages: 11
DOI: 10.2174/1872208310666160919122155
Price: $65

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