Systemic Delivery of Nanoformulations of Anti-cancer Drugs with Therapeutic Potency in Animal Models of Cancer

Author(s): Md. Emranul Karim, Rozita Rosli, Ezharul H. Chowdhury.

Journal Name: Current Cancer Therapy Reviews

Volume 12 , Issue 3 , 2016

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Abstract:

Despite being widely used for cancer treatment, conventional chemotherapeutic regimens based on anti-cancer drugs possess significant drawbacks in discriminating between normal and cancer cells, leading to detrimental effects on healthy tissues. The development of nano-formulations encapsulating the chemotherapy drugs is highly expected to improve the anti-cancer activities with favorable pharmacokinetic profile and consequentially minimized side-effects. Several organic and inorganic nanoparticles have received tremendous attention as carriers of various anticancer drugs in pre-clinical and clinical settings. In this review, we discuss on the progress of formulating and investigating various nano-formulationsin treating different cancers, with an emphasis on in vivo studies utilizing the nanoparticles for carrying small molecular weight anti-cancer drugs and focusing on the biocompatibility, targeting capability, cellular uptake, and the tumor regression efficacy of those nano-formulations.

Keywords: Cancer, multi-functional nanoparticle, anti-cancer drug, active targeting, passive targeting, EPR effect, controlled release.

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Article Details

VOLUME: 12
ISSUE: 3
Year: 2016
Page: [204 - 220]
Pages: 17
DOI: 10.2174/1573394712666160919101827
Price: $58

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