Lung diseases cause great morbidity and mortality. The choice of effective medical treatment
is limited and the number of lung diseases are difficult to treat with current treatments. The embryonic
stem cells (ESCs) have the potential to differentiate into cell types of all three germinal layers, including
lung epithelial cells. So they can be a potential source for new cell therapies for hereditary or acquired
diseases of the airways and lungs. One method for treatment of lung diseases is cell therapy and the use of
ESCs that can replace the damaged epithelial and endothelial cells. Progress using ESCs has developed
slowly for lung regeneration because differentiation of lung cells from ESCs is more difficult as compared
to differentiation of other cells. The review studies the therapeutic effects of differentiated lung
cells from embryonic stem cells in lung diseases. There are few studies of differentiation of ESCs into a
lineage of respiratory and then investigation of this cell in experimental model of lung diseases.
Keywords: Cell therapy, ESCs, lung diseases, regeneration.
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