The renoprotection of erythropoietin (EPO) and its derivatives such as helix B surface peptide
(HBSP) have attracted a great deal of attention from scientists and clinicians alike. The evolutional
achievement in the dissociation of tissue protection and erythropoiesis is obtained through HBSP characterisation
and synthesis. We performed a series of studies using EPO, as well as HBSP, in a variety of
biological models subjected to transplant-related renal injuries such as ischemia reperfusion injury (IRI)
and/or immunosuppressant nephrotoxicity. In this short review, we would like to address the effects of
EPO in different formats, and its underlying mechanisms with focuses on apoptosis and inflammation
in in vitro, ex vivo and in vivo renal injury models, and to further explore potential applications and
challenges in humans.
Keywords: Erythropoietin, helix B surface peptide, ischemia reperfusion injury, inflammation, apoptosis and oxidation.
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