In the past decade, rapid developments in stem cell studies have occurred. Researchers
have confirmed the plasticity of bone marrow stem cells and the repair and regeneration effects of
bone marrow hematopoietic stem cells on solid organs. These findings have suggested the possibility
of using bone marrow stem cell mobilizers to repair and regenerate injured organs. Recent studies on
the effects of granulocyte colony-stimulating factor (G-CSF) and Plerixafor (AMD3100) on mouse
acute kidney injury models have confirmed that the use of bone marrow stem cell mobilizers may be
an effective therapeutic measure. This paper summarizes studies describing the effects of G-CSF and
AMD3100 on various acute kidney injury models over the past 10 years.
Keywords: Acute kidney injuries, granulocyte colony-stimulating factor, plerixafor, bone marrow stem cells.
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