Abstract
Diabetes is a chronic metabolic disorder characterized by increased level of glucose in the blood due to defects in insulin action, insulin secretion or both. The effective management of diabetes is extremely important, otherwise, chronic uncontrolled diabetes could lead to diabetes late complications namely neuropathy, retinopathy, cardiomyopathy and nephropathy. The survey has shown that diabetes mellitus is one of the five leading causes of death all over the world. The therapeutic agents in clinical practice are facing the challenge of several unwanted effects, ineffectiveness in a large population and patient compliance therefore, new effective therapies are most warrant. In this connection, the natural product could be the best option as already accepted therapeutic modality since time immemorial. This review encounters various plant derived glycosides with antidiabetic effects; mediated through different mechanism(s). It is concluded that focusing glycosides as antidiabetic therapy could lead to the discovery of some new effective therapeutic agents.
Keywords: Antidiabetic effects, antidiabetic therapy, diabetes mellitus, mechnism(s), plantglycosides, therapeutic agents.
Mini-Reviews in Medicinal Chemistry
Title:Phyto-glycosides as Therapeutic Target in the Treatment of Diabetes
Volume: 18 Issue: 3
Author(s): Sumaira Khattak and Haroon Khan*
Affiliation:
- Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, KPK,Pakistan
Keywords: Antidiabetic effects, antidiabetic therapy, diabetes mellitus, mechnism(s), plantglycosides, therapeutic agents.
Abstract: Diabetes is a chronic metabolic disorder characterized by increased level of glucose in the blood due to defects in insulin action, insulin secretion or both. The effective management of diabetes is extremely important, otherwise, chronic uncontrolled diabetes could lead to diabetes late complications namely neuropathy, retinopathy, cardiomyopathy and nephropathy. The survey has shown that diabetes mellitus is one of the five leading causes of death all over the world. The therapeutic agents in clinical practice are facing the challenge of several unwanted effects, ineffectiveness in a large population and patient compliance therefore, new effective therapies are most warrant. In this connection, the natural product could be the best option as already accepted therapeutic modality since time immemorial. This review encounters various plant derived glycosides with antidiabetic effects; mediated through different mechanism(s). It is concluded that focusing glycosides as antidiabetic therapy could lead to the discovery of some new effective therapeutic agents.
Export Options
About this article
Cite this article as:
Khattak Sumaira and Khan Haroon*, Phyto-glycosides as Therapeutic Target in the Treatment of Diabetes, Mini-Reviews in Medicinal Chemistry 2018; 18 (3) . https://dx.doi.org/10.2174/1389557516666160909112751
DOI https://dx.doi.org/10.2174/1389557516666160909112751 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
Natural Products in Drug Discovery
Natural products have always been one of the important ways of drug discovery due to their novel skeleton and diverse functional group characteristics. According to statistics, between 1981 and 2019, the FDA approved a total of 1,394 small molecule drugs for marketing, of which 930 marketed drugs originated from the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Endothelial Expression of MHC Class II Molecules in Autoimmune Disease
Current Pharmaceutical Design MicroRNAs as Early Biomarkers in Obesity and Related Metabolic and Cardiovascular Diseases
Current Pharmaceutical Design Cellular Therapy for Myocardial Repair
Current Cardiology Reviews Reductive Stress: A New Concept in Alzheimer’s Disease
Current Alzheimer Research Stem Cell Therapy for the Treatment of Myocardial Infarction
Current Pharmaceutical Design Emerging Roles of Cysteine Cathepsins in Disease and their Potential as Drug Targets
Current Pharmaceutical Design MicroRNA 21 Emerging Role in Diabetic Complications: A Critical Update
Current Diabetes Reviews Takotsubo Cardiomyopathy: What we have Learned in the Last 25 Years? (A Comparative Literature Review)
Current Cardiology Reviews Perioperative Management of Intracranial Aneurysm and Subarachnoid Hemorrhage
Current Pharmaceutical Design Comparison of High-Sensitive CRP, RDW, PLR and NLR between Patients with Chronic Obstructive Pulmonary Disease and Chronic Heart Failure
Current Respiratory Medicine Reviews Sleep-Disordered Breathing and Cardiovascular Disease: Exploring Pathophysiology and Existing Data
Current Respiratory Medicine Reviews The Involvement of Metallothioneins in Mitochondrial Function and Disease
Current Protein & Peptide Science Persistent Pulmonary Hypertension of the Newborn: Physiology, Hemodynamic Assessment and Novel Therapies
Current Pediatric Reviews Matrix Metallopropteinases in Heart Failure
Current Topics in Medicinal Chemistry Thyroid Disorders in Chronic Heart Failure: From Prognostic Set-up to Therapeutic Management
Endocrine, Metabolic & Immune Disorders - Drug Targets Identification and Characterization of New Proteins in Podocyte Dysfunction of Membranous Nephropathy by Proteomic Analysis of Renal Biopsy
Current Pharmacogenomics and Personalized Medicine Targeting the AMP-Activated Protein Kinase for the Treatment of Type 2 Diabetes
Current Drug Targets - Immune, Endocrine & Metabolic Disorders MicroRNAs in Atrial Fibrillation
Current Medicinal Chemistry EDITORIAL [Hot Topic: Transthyretin: A Small Protein in the Big World of Amyloidoses (Guest Editors: Adriano Martinelli and Gabriella Ortore)]
Current Medicinal Chemistry Irbesartan: Second Generation of ARB as Metabosartan
Current Hypertension Reviews