Background: Present work deals with the development of a hydrophilic drug encapsulated self healed microparticles.
Objective: To develop encapsulated microparticles of Ciprofloxacin, model hydrophilic drug.
Method: A modified o/o/w multi emulsion solvent evaporation method was used for the development of Ciprofloxacin encapsulated microparticles. Aluminium hydroxide was used as a healing agent. This method produced encapsulated carrier for hydrophilic drug and sustained release system. Microparticles were evaluated by using 3-level factorial design.
Results: The obtained encapsulated microparticles were characterized by FTIR, FESEM and elemental
analysis. The variables such as plymer (X1
) and aluminium hydroxide (X2
) were optimized for the maximum encapsulation efficiency (Y1
) and the optimum drug release (Y2)
with the help of the response surface methodology (RSM). The RSM predicted that, both X1
were significant for the Y1
(pvalues- 0.0006 & 0.0023) and Y2
(p- values-0.0003 & <0.0001). An increase in the concentrations of the polymer and aluminium hydroxide increased Y1
and decreased Y2
. The obtained optimum value of Y1
were 80.86 and 55.34, respectively. Those were well in agreement with the predicted value by RSM. In- vitro drug release study was also performed and data were checked for various kinetic models to confirm the sustained release behaviour of the microparticles.
Conclusion: The results showed that concentration of ethylcellulose and aluminium hydroxide greatly influenced the % encapsulation efficiency and drug release. The absence of drug polymer interactions was confirmed by FTIR spectroscopy. In-vitro drug release analysis and its kinetic modelling confirmed the sustained release behaviour of the microparticles.