Background: Allylic amination via acid catalyzed activation of a leaving
group is promoted by non-expensive and low toxicity Lewis acid and Bronsted acid
catalysts to give valuable allyl amine derivatives. In many cases, non-toxic byproducts
such as water or acetic acid are generated. Moreover catalysts that perform
the reactions in water as a solvent and the use of recyclable catalysts have been developed.
Methods: Peer-reviewed research literature methods on allylic amination via acid
catalyzed activation were compiled using data bases such as Sci-Finder and Scopus.
Results: The mini-review summarizes the most important methods for allylic amination
via acid catalyzed activation of a leaving group in the recent decade. These are
divide in two main groups - Lewis acid and Bronsted acid catalysed reactions.
Conclusion: Allylic amination via acid catalyzed activation of a leaving group meet criteria of the green
chemistry paradigm which has motivated method development for this type of reaction in recent years.
Keywords: Allylic substitution, allylic amination, lewis acids, bronsted acids, green chemistry, allylic alcohols, carbenium ion.
Rights & PermissionsPrintExport