A number of biological and clinical characteristics typical of late life depression
(LLD) have been suggested by recent research findings. The close association of LLD with
cognitive impairment is now well documented and evidenced. However, it is still not clear
whether it is depression that leads to cognitive decline, and in more severe cases, to dementia.
The work presented in this review article suggests that depression and dementia frequently
and strongly copresent, even if the causality remains largely opaque.
Keywords: Aging, Alzheimer disease, depression, dementia, BDNF late-life depression.
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