Beyond both being biphasic/bidirectional disorders (hypo)mania and essential hypertension
share a surprising number of similarities and an overlap between their genetics, biological background,
underlying personality and temperamental factors, precipitating factors, comorbidity and response to
treatment, indicating a possibly partially shared biological background. Based on theoretical knowledge,
similarities related to characteristics, manifestation and course, and the results of pharmacological studies
related to the effects and side effects of pharmacotherapies used in the treatment of these two distinct
disorders, the authors outline a hypothesis discussing the similar origins of these two phenomena and thus
mania being the hypertension of mood in memory of Athanasios Koukopoulos, one of the greatest
researchers and theoreticists of mania of all time.
Keywords: Bipolar disorder, comorbidity, hypertension, mania, temperament, underlying mechanisms.
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